M-Duo Technology® — Dermal interstitial fluid sampling
The M-Duo Technology® enables direct, localized access to the dermal compartment for biomarker sampling using microneedles. The dermis is the site where key biological processes relevant to inflammatory skin diseases take place. Within the dermis, soluble biomarkers are present in dermal interstitial fluid, a fluid matrix surrounding skin cells that reflects ongoing molecular and immunological activity.
The technology enables localized exchange at the microneedle tips: a carrier fluid is introduced and immediately retrieved together with dermal interstitial fluid. The resulting sample contains soluble molecular signals from the immediate vicinity of the microneedles, enabling analysis of proteins, cytokines, and other biomarkers, without removing tissue.
By providing dermal access using a minimally invasive microneedle approach, the M-Duo Technology® is designed to reduce procedural burden for clinical trial participants compared to dermal sampling methods that require tissue removal. This supports localized and repeat sampling over time and enables study designs that are difficult to implement with tissue-based dermal procedures. By lowering practical barriers to accessing dermal biology, the technology supports more feasible translational research workflows, particularly in dermatology studies where biopsy-related burden can impact enrollment and retention.
